Dr.MANABJYOTI BARMAN

DR. DIPANKAR DAS

Abstract

Purpose:To analyze H2S and VEGF level in serum and vitreous of DR of varied severity and non diabetic controls; and to analyze their association with systemic factors. Method:150 patients were enrolled in this prospective, case-control study . H2S was estimated by spectrophotometry and VEGF by ELISA . Systemic parameters analyzed were- FBS, HbA1C, Hb%, BMI, smoking habit, lipid profile, Serum Cr and BP. Results: H2S levels in vitreous were 55.26± 3.41, 55.52±2.78, 57.05±4.04, 61.03±3.01,64.51±4.97 and in serum were 54.13±3.31, 54.47±2.02, 55.63±3.26, 57.83±3.20 & 61.96±4.67 in control, mild NPDR, mod NPDR, severe NPDR & PDR respectively. VEGF levels in serum were 154.26±10.78, 163.43±4.64, 170.93±9, 201.42±19.9, 321.6±70.24 and in vitreous were 165.65±11.24, 177.06±8.6, 228±31.4, 453.36±86.6, 819.8±119.4 in controls, mild NPDR, mod NPDR, severe NPDR and PDR respectively. Conclusion: H2S and VEGF levels in the vitreous and serum shows a positive correlation with severity of DR.

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