DR. NIKITA GUPTA

Dr. DEEKSHA KATOCH, Dr.SIMAR RAJAN SINGH, Dr. MANGAT R. DOGRA

Abstract

Thirty six infants(72 eyes) with zone1 ROP were prospectively randomized equally to laser photocoagulation(LP) and intravitreal Ranibizumab(IVR) injection. Demographic details,risk factors,disease characteristics,response to therapy,axial length (AL),cycloplegic retinoscopy,keratometry,lens thickness(LT) and anterior chamber depth (ACD) were recorded at baseline and at 3,6 and 12 months after treatment.The mean gestational age and birth weight were comparable at baseline.At 3 months,92.85%eyes(LP) achieved ROP regression compared to 76.66% eyes(IVR)(p=0.049) with comparable biometric parameters. At 1yr,LT was higher in LP eyes but differences in AL as well as the mean spherical equivalent of refraction were insignificant.

LP showed comparable anatomical outcomes to IVR in zone1 ROP. Though deferring laser by IVR seemed to outdo development of some of the biometric changes, refractive errors were comparable at 1year thus implying that zone of disease also contributes to myopia in ROP.

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