DR. RUPALI BARNWAL

DR.MEHUL SHAH, DR. SHREYA SHAH

Abstract

OBJECTIVE: TO STUDY EFFICACY OF METHOTREXATE COMPARED TO SYSTEMIC CORTICOSTEROIDS FOR MEDICAL TREATMENT OF EALES DISEASES.

METHODS: RETROSPECTIVE ANALYSIS OF PATIENT CLINICALLY DIAGNOSED WITH EALES DISEASE BETWEEN 2008-2022 DONE.WE HAVE DIVIDED MEDICALLY TREATED PATIENTS IN TWO GROUPS CORTICOSTEROIDS AND METHOTREXATE IN ADDITION WITH POSTERIOR SUBTENON STEROID.STATISTICAL ANALYSES DONE WITH SPSS22,DESCRIPTION AND CROSSTABULATION USED FOR ANALYSIS.

RESULTS: OUR COHORT COMPRISED OF 366 CASES WITH MEDIAN FOLLOW-UP DURATION OF 398 DAYS.OUT OF THAT 29 PATIENTS WERE TREATED WITH METHOTRAXATE IN ADDITION TO POSTERIOR SUBTENON & FOUND LAST VISIT BCVA > 6/18 IN 13(44.42%)PATIENTS.248 PATIENTS WERE TREATED WITH ORAL STEROID IN ADDITION TO POSTERIOR SUBTENON STEROID ACHIVED BCVA>6/18 IN 121(48.79%) PATIENTS.WE DID NOT FIND SIGNIFICANT DIFFERENCE IN VISUAL OUTCOME BETWEEN TWO GROUPS(P=0.18).

CONCLUSION: EFFICACY OF METHOTREXATE IS AN EQUAL WHEN COMPARED TO SYSTEMIC CORTICOSTEROIDS.