DR. MANUMURALEEKRISHNA

Prof.BHAVNA CHAWLA, Dr. SEEMA SEN, Dr.NEIWETE LOMI

Abstract

Aim: To compare histopathological high risk factors (HRF) in enucleated eyes undergoing primary or secondary (post-chemotherapy) enucleation for retinoblastoma.

Methods: 175 enucleated specimens were evaluated – Group 1 with primary and Group 2 with secondary enucleation. Histopathological HRF were compared between both groups.

Results: Of 175 eyes, 90 were Group 1 & 85 were Group 2. Among HRF, post-laminar optic nerve invasion was more significant in Group 1(31/90 vs 15/85,p-0.01), whereas optic nerve cut end (1/90 vs 9/85, p-0.007) & anterior segment invasion (12/90 vs 22/85,p-0.03) were higher in Group 2. There was no significant difference between massive choroidal invasion (22/90 vs 9/85,p-0.13) and scleral involvement (9/90 vs 9/85, p-0.89) between both groups.

Conclusion: Attempt to save an eye and delay in enucleation can impose additional risks to the life of the child. Thus, a cautious and balanced approach is needed between life and globe salvage in retinoblastoma.

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