DR. NITIKA PANDEY

Dr.ANIKET SHASTRI, Dr.Satyamurthy K V

Abstract

Aim: To assess the effectiveness of novel “sub400 protocol” in halting the progression of advanced keratoconus.

Design- Prospective interventional case series

Methods: 15 eyes of 10 patients with advanced progressive keratoconus with thinnest pachymetry (T-CT) 238-395 um underwent CXL with irradiation at 3mW/cm2 and fluence adapted to the thinnest pachymetry. Change in BCVA, manifest refraction, steepest keratometry, T-CT, demarcation line (DL) depth and endothelial cell density (ECD) were recorded at 1, 3 and 6 months follow up.

Results: Fourteen (93%) showed no progression of the disease at 6 months follow up. A significant correlation was found between DL-depth and irradiation time (r=+0.542, p=0.002) No significant changes were found in BCVA (p=0.560), sphere (p=0.124) or cylinder (p=0.712), ECD (p=0.673) and steepest keratometry (p=0.062).

Conclusion: The “sub400” protocol is effective in halting keratoconus progression in 93% cases with thin corneas in advanced keratoconus.

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