DR. PRINCY M

DR. VIRNA SHAH, Dr. KARTHIK KUMAR MANI

Abstract

MOG IgG associated optic neuritis (O.N) is important to diagnose as the treatment approach varies between MS,NMO & MOG associated O.N. Aim:To determine the incidence, clinical presentation & radiological findings of MOG IgG associated O.N..Materials & Methods: We included 35 patients (pts) within 4 months (Dec.21- March 22).Pts >16 yrs.Recurrent,unilateral,bilateral O.N were included.After clinical diagnosis & confirmation by MRI,antiMOG Ab test was done & treated as per ONTT. Results: Out of 35 pts,8 (22.8%) were MOG IgG +ve.Bilaterality seen 4 pts(50%)&pain in 8 eyes(67%) .12 eyes of 8 pts included in study.Among them,9 eyes had papillitis(75%) & 3 had RBN.Female preponderance was 87.5 %.MRI s/o increased signal intensity involving intraorbital part in 9 eyes(75%).Conclusion:MOG IgG associated O.N. is usually bilateral with female preponderance.MRI features also quite specific with chiasma not affected. Neurologist referral required for immunotherapy to avoid recurrences.

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