DR. SURUTHI NAGARAJAN

Dr. RAJESH PRABU VELLAICHAMY, DR. SHRUTI MOHAN

Abstract

Vigabatrin(VGB) has been commonly used to treat epilepsy and has been recently approved in India to treat Infantile Spasms. However, prolonged use of VGB causes retinal damage and visual field defects. VGB-induced retinal toxicity is manifested by visual field loss, which occurs in 52% of adults and 34% of children treated with VGB. As visual field testing in children is challenging, alternative methods to detect early VGB toxicity are needed.

We report a case series of 9 children with infantile spasms on different doses of VGB. A 30 Hz Flicker potential ERG using REtEval was done at baseline before starting VGB, at 6 months and at 1 year and amplitudes were recorded. The mean age was 18 months. Six of the nine children showed reduced amplitudes, and all these 6 children were on VGB for more than 6 months. We conclude that ERG can be used as a tool for VGB toxicity monitoring.

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