DR. ANSHIKA LUTHRA

Dr. SWATHI KALIKI

Abstract

Purpose: To assess long-term outcomes of systemic chemotherapy for periocular sebaceous gland carcinoma (SGC)

Methods: Retrospective study of 6 cases

Results: Mean age at diagnosis was 52 years; 5 (83%) were females. Mean tumor basal diameter was 37 mm with orbital extension in all cases. As per 8th edition AJCC classification, they were classified as T4 (n=6), N1 (n= 3), and M1 (n=2). Mean number of systemic chemotherapy cycles was 3. Mean percentage reduction of tumor basal diameter after chemotherapy was 88%. No major systemic side-effects were reported. Post-chemotherapy, all cases received EBRT and surgical treatment for residual tumour was performed in 3 cases (excision biopsy(n=1) and lid-sparing orbital exenteration (n=2). At a mean follow-up period of 41 months, none developed tumor recurrence and 1 died due to systemic metastasis.

Conclusion: Neoadjuvant chemotherapy is an effective and safe treatment modality for extensive periocular SGC with favorable long-term outcomes.

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