DR. DEBOLINA DEB

Dr..Muthayya Muthukumar, Dr. RADHA K. ANNAMALAI

Abstract

To correlate Vitamin D levels in 1st month of life with preterm babies developing ROP.

A case-control,age matched study in South India-27 preterm babies with ROP (cases) and 27 without ROP (controls). Inclusion:GA less than 34 weeks and BW less than 2000 grams. Serum Vitamin D checked in 4th week of life, after starting multivitamin supplements (day 14).ROP screening done from 31 weeks PCA or 3rd week of life,based on ICROP and ETROP classification.Serum 25-OH vitamin D < 30 ng/ml considered insufficient. We compared 15 other risk factors between the groups. Babies with ROP had lower GA, BW and serum 25-hydroxyvitamin D levels (p < 0.05), especially with type 1 ROP.Anemia and history of multiple blood transfusions were associated with type 1 ROP(p<0.05). Vitamin D deficiency existing through 3rd week in preterm babies significantly contributes towards progression of ROP due to angiogenesis.We could use Vitamin D levels as a predictive biomarker for progression to ROP at an early age.

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