DR. TASNEEM NEEMUCHWALA

DR.PREM ANAND CHANDRAN, DR. MRUNALI DHAVALIKAR, DR. GANESH V. RAMAN

Abstract

Purpose: To compare the efficacy of topical Non-steroidal anti-inflammatory drugs (NSAID) versus topical steroids in controlling anterior chamber inflammation after laser iridotomy in primary angle closure suspects(PACS).

Methods: Participants with bilateral PACS numbering 158 were randomized to two groups, topical Nepafenac 0.1% (tid x 14 days) and topical Prednisolone acetate 1% (qid x 5 days). Investigators were masked to the type of medication.

Results: No statistical significant difference was observed with respect to intraocular pressure, anterior chamber depth, or gonioscopic opening of the angle before and after LPI. At the 1st week visit, six patients in the Nepafenac group had anterior chamber reaction which resolved with conservative treatment. None of the participants from either group presented with rebound iritis.

Conclusions: Short course of topical steroids under close monitoring helps in preventing steroid induced raised IOP and rebound inflammation.