Dr.LIONAL RAJ

Abstract

Purpose: To evaluate safety of implanting synthetic corneal endothelial substitute in cases of chronic endothelial dysfunction

Methods: A prospective open-label clinical safety evaluation. Cases of chronic endo.dysfn. were subjected to synthetic implant after a central 7.5mm descemetorhexis & attached under gas similar to endo.keratoplasty. Pre & post-op CCT, vision (ETDRS characters), pain scores were analysed in addition to re-bubbling rates & toxic reactions.

Results: 12 cases enrolled. Vision at baseline was 9.75+/-1.7 characters, which improved to 41.75+/-8.7, and retained after 4mon. at 50.59+/-7.1. CCT reduced from 715mic, to 504 & maintained at 472.5 by mon4. Pain, out of a scale of 1 -100, at presentation was 90.5+/-2.3 & 68.25+/-4.03 at 1mon, further improved by mon.3.

No immunologic reactions were noticed in any cases. 3 cases needed rebubbling (D7, D7, D21)

Conclusion: Synthetic endothelial layer improved vision, reduced corneal edema & were not associated with toxicities.

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