DR. MITHUN THULASIDAS

Abstract

A five-year retrospective observational comparative case study was conducted including 15 advanced keratoconus eyes of unilateral keratoconus (KCN group), 15 normal fellow eyes of unilateral keratoconus (Fellow eye group) and 34 eyes of normal refractive surgery candidates (Normal group). Topographic and tomographic data, data from enhanced elevation maps, and keratoconus indices were measured in all study eyes using Pentacam. Corneal thickness at the apex (P=0.001) and at the thinnest point (P<0.001), corneal volume (P=0.007), BAD-thinnest point (P=0.002) and thinnest point displacement (P=0.002) were significantly lower in the fellow group compared to normal group. On ROC curve analysis, the most efficient distinguishing indices between the fellow group and normal controls were BAD-overall D value (AUC=0.859), Dt, Da, followed by pachymetric progression index (PPI) maximum (AUC=0.741). BAD-D value and PPI could be useful in detecting the earliest form of subclinical keratoconus.

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