DR. RESHMA PADMARAM NAIR

Dr.Monika Kapoor, Dr.MAHESH KUMAR

Abstract

We compared the outcomes of intravitreal ranibicizumab+triamcinolone(2mg) with monotherapy in treatment naiive DME & RVO patients with CMT more than 500microns.It was a single centre prospective study done on 54 eyes with 3 months follow up.Group A received combination and B monotherapy after simple randomization.OCTs were obtained from Spectral Domain OCT and PRN regimen was followed.Both groups were matched for age, gender and diagnosis.At 3 weeks,3 lines improvement was noted in 19% in A and 3.6% in B.At 3 months,3lines improvement was noted in 42%(p <0.002) with single injection in group A,whereas in groupB it was only 4.3% with average 1.8 injections.CMT reduction post 2 months in group A was 61.36 +/-150 microns which is higher than -30.16+/-179 group B.Conclusion:Combination therapy was safe and was found to have significant gain in visual acuity and improved CMT reduction with lesser number of injections thereby reducing the treatment burden and better cost effectiveness.

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